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Crestor is considered a more potent statin, while Lipitor has been FDA-approved longer than Crestor. On some measures, patients taking Crestor did better than those on Lipitor: LDL levels in the Crestor group dropped to an average 62. Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. "Unbelievable savings iStockphoto. Lipitor (atorvastatin) improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease.. Both drugs are very popular and many patients are treated with them. Comparison - positive and negative sides. Both Lipitor and Crestor are excellent medications to help improve high cholesterol and to decrease your risk of heart attacks and strokes. The active ingredient in Lipitor is atorvastatin. 7 / 5 average rating with 751 reviews forCrestor Lowers cholesterol. The active ingredient in Crestor is rosuvastatin. Crestor is the trade name for Rosuvastatin and Lipitor is the trade name for Atorvastatin. 2 mg/dL for patients on Lipitor. (CBS/AP) Drug-maker AstraZeneca gambled on a study that pitted its cholesterol-lowering drug Crestor Pfizer's Lipitor. Rosuvastatin (Crestor) is a highly effective statin medication. People of Asian descent may be more more Prescription only. They might have a similar mechanism of action but there are some differences, which must be pointed out. The gamble didn't pay off - Crestor proved no better at. It is used to improve cholesterol levels, lower triglycerides, and to protect the heart and blood vessels. It is also used for people who are at higher risk of heart disease (such as those with diabetes) even though they may have normal cholesterol levels. It's also available as a generic.